OM-X contributes to regulate immune system and protect cells (a collaborative research with Hokkaido Pharmaceutical University School of Pharmacy)

Date 2017/02/23

OM-X contributes to regulate immune system and protect cells (a collaborative research with Hokkaido Pharmaceutical University School of Pharmacy)

BIOBANK CO., LTD. (located in Okayama City, Okayama Prefecture) has performed a collaborative research with associate professor Koji Wakame and his study group from the Department of Pharmacology at Hokkaido Pharmaceutical University School of Pharmacy (located in Sapporo City, Hokkaido). The fermented vegetable extract (OM-X) showed a potential to regulate the immune system and protect cells.

The results have been presented at the 23rd Meeting of the Japan Mibyou System Association in November 2016 and published in the Integrative Molecular Medicine in January 20, 2017.

 

Abstract

BIOBANK CO., LTD. develops and produces an extract (OM-X) that was made with fermented vegetables, fruits, seaweeds, mushrooms and other ingredients. Unfortunately, it is difficult to show the specific scientific basis about the function of health foods, which are a mixture of various kinds of raw materials like OM-X, to living organisms.

 

Based on this background, BIOBANK CO., LTD. has conducted a collaborative research with associate professor Koji Wakame from Hokkaido Pharmaceutical University School of Pharmacy in order to find the functionality and mechanisms of OM-X.

The in vitro study showed that the macrophages from mice were activated by OM-X. The in vivo study also showed that the administration of OM-X causes the change in the gene expression in the liver of the mice which will inhibit inflammation and protect cells.

 

Procedures

We added OM-X to a culture of lower gastrointestinal tract cells from rats and measured the production of GLP-1, one of the hormones which promotes the secretion of insulin, by enzyme-linked immunosorbent assay (ELISA). According to the results, the production of GLP-1 in the gastrointestinal tract cells increased proportionally with the added amount of OM-X (Chart1).

 

We added OM-X to a culture of macrophages from mice (RAW264.7 cells) and measured the production of nitric oxide (NO) which is an indicator of the activity of macrophages and cytokines (IL-6TNF-α) which activates the immune system. Regarding the production of NO and cytokines, both were increased by adding OM-X. It showed that OM-X stimulates macrophages directly and activates the immune system (Chart2).

 

Furthermore, we administered OM-X to the mice and measured the expression levels of 597 genes in the liver. As a result, the expression level of 4 genes increased and the expression level of 23 genes decreased. Since the decreased 23 genes were involved into inflammation and apoptosis (cell death), this result suggested that the ingestion of OM-X provides the effects of suppressing inflammation in the liver and protecting cells (Chart3).    



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